RA are considered relatively quiescent lesions with little potential for progression, however in rare cases they may exhibit aggressive behaviours including rapid growth, exudative retinal detachments and neovascular glaucoma. They are the best-known ocular manifestation of tuberous sclerosis (TS) but can be idiopathic or associated with neurofibromatosis. Most patients are asymptomatic, therefore RA are usually discovered as an incidental finding. Retinal astrocytomas (RA) are rare tumours which arise from retinal glial cells. We advise using multiple imaging modalities when diagnosing these lesions. RAs display characteristic clinical, demographic and imaging features which can aid differentiating them from other non-pigmented fundal lesions. High internal reflectivity on US was noted in 92% (11/12). Mean basal diameter and thickness on OCT was 2.93 mm and 0.86 mm, respectively. On OCT, all appeared as dome-shaped retinal thickening with disruption of the inner retinal layers and nine (60% 9/15) had intra-retinal cystic spaces giving a ‘moth-eaten’ appearance. Six (33% 6/18) displayed clustered, calcified spherules giving them the pathognomonic ‘mulberry-like’ appearance. There were two distinct appearances, seven (39% 7/18) were poorly-defined translucent retinal elevations and eleven (61% 11/18) were well-defined solid opaque retinal masses. Twelve patients (71% 12/17) were asymptomatic. Resultsįourteen patients (82% 14/17) had idiopathic RA and three (18% 3/17) were associated with tuberous sclerosis. These were compared to differential diagnoses, including retinoblastomas, amelanotic choroidal melanomas, choroidal metastases and idiopathic scleromas. Demographics, examination findings and imaging including colour fundus photography, optical coherence tomography (OCT), infra-red (IR) and ultrasound (US) were analysed. Retrospective analysis of notes and imaging of 17 patients diagnosed with RA at a single centre between January 2012 and June 2021 was conducted. To use multimodal imaging techniques to characterise features of retinal astrocytomas (RA) which would aid practitioners distinguish them from other causes of non-pigmented fundal lesions.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |